Yu-Ju Lee, Ph.D.
  • Ph.D. in Translational Biology and Molecular Medicine, Baylor College of Medicine, USA
  • M.S. in Biochemistry and Molecular Biology, Georgetown University, USA​​
  • Yu-Ju is interested in using advanced molecular and neurobiology methods to study therapies for ASDs. She is also interested in neuronal miswiring underlying neurogenesis and neurodevelopmental disorders. In her spare time, she likes to watch movies and cartoons, listen to music, and play puzzles

Publications
​Kowalczyk M, Lee YJ, Huang WH
TSC2-mTORC1 axis regulates morphogenesis and neurological function of Gli1+ adult-born dentate granule cells
Mol Biol Cell, 2024 Nov 27:mbcE24080366. doi: 10.1091/mbc.E24-08-0366

Katz N, An C, Lee YJ, Tycko J, Zhang M, Kang J, Bintu L, Bassik MC, Huang WH, Gao X
Tunable, self-contained gene dosage control via proteolytic cleavage of CRISPR-Cas systems
bioRxiv, [Preprint]. 2024 Oct 9:2024.10.09.617463. doi: 10.1101/2024.10.09.617463. 

Chang YT, Lee YJ, Haque M, Chang HC, Javed S, Lin YC, Abramovitz J, Chin G, Khamis A, Raja R, Murai KK, Huang WH
Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys
J Comp Neurol., 2024 Jan;532(1):e25589. doi: 10.1002/cne.25589.​

Javed S, Chang YT, Cho Y, Lee YJ, Chang HC, Haque M, Lin YC, Huang WH
Smith-Magenis syndrome protein Rai1 regulates body weight homeostasis through hypothalamic Bdnf-producing neurons and neurotrophin downstream signalling
Elife, 2023;12:RP90333. doi.org/10.7554/eLife.90333.3

Chang HC, Lee YJ, Javed S, Haque M, Chang YT, Lin YC, Oram C, Huang WH 
rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice
J Biol Chem, 2023 Jan, doi: 10.1016/j.jbc.2022.102728

Chang YT, Kowalczyk M, Fogerson PM, Lee JY, Haque M, Adams EL, Wang DC, DeNardo LA, Tessier-Lavigne M, Huguenard JR, Luo L, Huang WH 
Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome
Proc Natl Acad Sci USA, 2022 Oct, doi.org/10.1073/pnas.2210122119

Javed S, Lee YJ, Xu J, Huang WH
Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis Syndrome.
Hum Mol Genet.; 2022 Jan doi.org/10.1093/hmg/ddab245

Javed S, Selliah T, Lee YJ, Huang WH (2020) Dosage-Sensitive Genes in Autism Spectrum Disorders: From Neurobiology to Therapy. Neurosci and Biobehav Rev.; S0149-7634(20)30547-9.doi: 10.1016/j.neubiorev.2020.08.009

Graves JD, Lee YJ, Liu K, Li G, Lin FT, Lin WC (2020) E2F1 sumoylation as a protective cellular mechanism in oxidative stress response. Proc Natl Acad Sci USA; 117(26):14958-14969. doi: 10.1073/pnas.1921554117. Epub 2020 Jun 15

Liu K, Graves JD, Lee YJ, Lin FT, Lin WC (2020) Cell cycle-dependent switch of TopBP1 functions by Cdk2 and Akt. Mol Cell Biol; 40:E00599-19. PMID: 31964753, PMCID: PMC7108819

Lee YJ, Ho SR, Graves JD, Xiao Y, Huang S, Lin WC (2019) CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer. Breast Cancer Res; 21:134. PMID: 31801577, PMCID: PMC6894136
 
Liu K, Lin FT, Graves JD, Lee YJ, Lin WC (2017) Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin. Proc Natl Acad Sci USA; 114:E3766-E3775. PMCID:PMC5441733, PMID:28439015
 
Ho SR, Lee YJ, Lin WC (2015) Regulation of RNF144A E3 ubiquitin ligase activity by self-association through its transmembrane domain. J Biol Chem; 290:23026-38. PMCID: PMC4645615, PMID: 26216882
 
Ho SR, Mahanic CS, Lee YJ, Lin WC (2014) RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage.  Proc Natl Acad Sci USA; 111:E2646-2655. PMCID:PMC4084471, PMID: 24979766