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Yu-Ju Lee, Ph.D.
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Publications
Chang HC, Lee YJ, Javed S, Haque M, Chang YT, Lin YC, Oram C, Huang WH
rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice
J Biol Chem, 2022, doi: 10.1016/j.jbc.2022.102728
Chang YT, Kowalczyk M, Fogerson PM, Lee JY, Haque M, Adams EL, Wang DC, DeNardo LA, Tessier-Lavigne M, Huguenard JR, Luo L, Huang WH
Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome
Proc Natl Acad Sci USA, Oct 25, 2022, doi.org/10.1073/pnas.2210122119
Javed S, Lee YJ, Xu J, Huang WH (2021) Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis Syndrome. Hum Mol Genet.; doi.org/10.1093/hmg/ddab245
Javed S, Selliah T, Lee YJ, Huang WH (2020) Dosage-Sensitive Genes in Autism Spectrum Disorders: From Neurobiology to Therapy. Neurosci and Biobehav Rev.; S0149-7634(20)30547-9.doi: 10.1016/j.neubiorev.2020.08.009
Graves JD, Lee YJ, Liu K, Li G, Lin FT, Lin WC (2020) E2F1 sumoylation as a protective cellular mechanism in oxidative stress response. Proc Natl Acad Sci USA; 117(26):14958-14969. doi: 10.1073/pnas.1921554117. Epub 2020 Jun 15
Liu K, Graves JD, Lee YJ, Lin FT, Lin WC (2020) Cell cycle-dependent switch of TopBP1 functions by Cdk2 and Akt. Mol Cell Biol; 40:E00599-19. PMID: 31964753, PMCID: PMC7108819
Lee YJ, Ho SR, Graves JD, Xiao Y, Huang S, Lin WC (2019) CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer. Breast Cancer Res; 21:134. PMID: 31801577, PMCID: PMC6894136
Liu K, Lin FT, Graves JD, Lee YJ, Lin WC (2017) Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin. Proc Natl Acad Sci USA; 114:E3766-E3775. PMCID:PMC5441733, PMID:28439015
Ho SR, Lee YJ, Lin WC (2015) Regulation of RNF144A E3 ubiquitin ligase activity by self-association through its transmembrane domain. J Biol Chem; 290:23026-38. PMCID: PMC4645615, PMID: 26216882
Ho SR, Mahanic CS, Lee YJ, Lin WC (2014) RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. Proc Natl Acad Sci USA; 111:E2646-2655. PMCID:PMC4084471, PMID: 24979766
Chang HC, Lee YJ, Javed S, Haque M, Chang YT, Lin YC, Oram C, Huang WH
rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice
J Biol Chem, 2022, doi: 10.1016/j.jbc.2022.102728
Chang YT, Kowalczyk M, Fogerson PM, Lee JY, Haque M, Adams EL, Wang DC, DeNardo LA, Tessier-Lavigne M, Huguenard JR, Luo L, Huang WH
Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome
Proc Natl Acad Sci USA, Oct 25, 2022, doi.org/10.1073/pnas.2210122119
Javed S, Lee YJ, Xu J, Huang WH (2021) Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis Syndrome. Hum Mol Genet.; doi.org/10.1093/hmg/ddab245
Javed S, Selliah T, Lee YJ, Huang WH (2020) Dosage-Sensitive Genes in Autism Spectrum Disorders: From Neurobiology to Therapy. Neurosci and Biobehav Rev.; S0149-7634(20)30547-9.doi: 10.1016/j.neubiorev.2020.08.009
Graves JD, Lee YJ, Liu K, Li G, Lin FT, Lin WC (2020) E2F1 sumoylation as a protective cellular mechanism in oxidative stress response. Proc Natl Acad Sci USA; 117(26):14958-14969. doi: 10.1073/pnas.1921554117. Epub 2020 Jun 15
Liu K, Graves JD, Lee YJ, Lin FT, Lin WC (2020) Cell cycle-dependent switch of TopBP1 functions by Cdk2 and Akt. Mol Cell Biol; 40:E00599-19. PMID: 31964753, PMCID: PMC7108819
Lee YJ, Ho SR, Graves JD, Xiao Y, Huang S, Lin WC (2019) CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer. Breast Cancer Res; 21:134. PMID: 31801577, PMCID: PMC6894136
Liu K, Lin FT, Graves JD, Lee YJ, Lin WC (2017) Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin. Proc Natl Acad Sci USA; 114:E3766-E3775. PMCID:PMC5441733, PMID:28439015
Ho SR, Lee YJ, Lin WC (2015) Regulation of RNF144A E3 ubiquitin ligase activity by self-association through its transmembrane domain. J Biol Chem; 290:23026-38. PMCID: PMC4645615, PMID: 26216882
Ho SR, Mahanic CS, Lee YJ, Lin WC (2014) RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. Proc Natl Acad Sci USA; 111:E2646-2655. PMCID:PMC4084471, PMID: 24979766