Huang Lab @ McGill
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McGill
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Chang HC, Lee YJ, Javed S, Haque M, Chang YT, Lin YC, Oram C, Huang WH
rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice
J Biol Chem., 2023 Jan; 102728, doi.org/10.1016/j.jbc.2022.102728

Chang YT, Kowalczyk M, Fogerson PM, Lee JY, Haque M, Adams EL, Wang DC, DeNardo LA, Tessier-Lavigne M, Huguenard JR, Luo L, Huang WH
Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome
Proc Natl Acad Sci USA, 2022 Oct 25;119(43):e2210122119., doi.org/10.1073/pnas.2210122119

Huang WH
Performing Single Cell Clonal Analysis in the Mouse Brain using Mosaic Analysis with Double Markers (MADM)
Methods Mol Biol., 2022 July
;2515:59-74. doi.org/10.1007/978-1-0716-2409-8_4

Javed S, Lee YJ, Xu J, Huang WH
Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis Syndrome
Hum Mol Genet., 2022 Jan;31(2):275-288, doi.org/10.1093/hmg/ddab245


​Javed S, Selliah T, Lee YJ, Huang WH
Dosage-Sensitive Genes in Autism Spectrum Disorders: From Neurobiology to Therapy 
Neurosci & Biobehav Rev.,
2020 Nov;118:538-567. doi.org/10.1016/j.neubiorev.2020.08.009

Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai ELL, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmuller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubesntein JL, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, Craig AM
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors 
Neuron
, 2020, April 8; 106 (1):37-65.e5
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Pre-McGill


Huang WH, Wang DC, Allen, WE, Klope M, Hu H, Shamloo M, Luo L
Early Adolescent Rai1 Reactivation Reverses Transcriptional and Social Interaction Deficits In a Mouse Model of Smith-Magenis Syndrome 
Proc Natl Acad Sci USA, 2018, Oct 16;115(42):10744-10749

​Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, van der Heijden ME, Gray PA, Xue M, Ray RS, Ren D, and Zoghbi HY
Respiratory network stability and modulatory response to substance P require Nalcn 
Neuron, 2017, Apr 19;94(2):294-303.e4

Huang WH, Guenthner CJ, Xu J, Nguyen N, Wilkinson AW, Gozani O, Chang HY, Shamloo M, Luo L
Molecular and Neural Functions of Rai1, The Causal Gene for Smith-Magenis Syndrome 
Neuron, 2016, Oct 19;92(2):392-406

Tupal S, Huang WH, Picardo MC, Ling GY, Del Negro CA, Zoghbi HY, Gray PA
Atoh1-dependent rhombic lip neurons are required for temporal delay between independent respiratory oscillators in embryonic mice 
Elife, 2014, May 14;3:e02265
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​Huang WH, Tupal S, Huang TW, Ward CS, Neul JL, Klisch TJ, Gray PA, Zoghbi HY
Atoh1 governs the migration of postmitotic neurons that shape respiratory effectiveness at birth and chemoresponsiveness in adulthood 
​Neuron, 2012, Sep 6; 75(5): 799-809
  • About the lab
  • Group Leader
  • Research
  • Publications
  • Group members
  • Resources
  • Montreal