McGill | Huang Lab
Molecular and Circuit Mechanisms of Autism, Epilepsy, and Neuropsychiatric Disorders
The Huang lab aims to improve brain health by unlocking the molecular and circuit mechanisms underlying autism, epilepsy, and neuropsychiatric disorders. We apply a wide spectrum of approaches including molecular biology (i.e. CRISPR), human iPSC models, mouse genetics, electrophysiology, single cell technology (Mosaic Analysis of Double Markers, MADM), and whole brain clearing and imaging. The ultimate goal is to translate discoveries to innovative solutions for mitigating and curing developmental brain disorders.
We are especially interested in
- Neurodevelopment: We study the regulation of circuit excitability at the molecular and cellular levels
- Neurodevelopmental disorders: Our main focus is Smith-Magenis syndrome, a neurodevelopmental disorder associated with autism, epilepsy, metabolic syndromes, and neuropsychiatric features
- Therapeutics: Identify novel drug targets and develop pharmacological and gene therapies for neurodevelopmental and neuropsychiatric disorders
We are based at the Centre for Research in Neuroscience (CRN), Department of Neurology and Neurosurgery at McGill University. Dr. Huang is a member of the Neurodevelopmental Disorders Research Group at the Montreal Neurological Institute (The Neuro) and McGill Regenerative Medicine Network
We are also affiliated with the Brain Repair and Integrative Neuroscience Program (BRaIN) at the Research Institute of the McGill University Health Centre (RI-MUHC), as well as the Azrieli Centre for Autism Research (ACAR)
Our lab is housed at the Montreal General Hospital, located at the golden square mile in the heart of downtown Montreal. Meanwhile, we are right net to Mt. Royal park with a lot of natural green space!
Lab address:
Research Institute of the McGill University Health Centre
1625 avenue des pins ouest, L11-144 and L11-132, Montreal, Quebec H3G 1A3, Canada
PI: Wei-Hsiang Huang
Phone: 514-934-1934 ext 47216 (office) ext 44895 (lab)
E-mail: wei-hsiang.huang at mcgill.ca
We are also affiliated with the Brain Repair and Integrative Neuroscience Program (BRaIN) at the Research Institute of the McGill University Health Centre (RI-MUHC), as well as the Azrieli Centre for Autism Research (ACAR)
Our lab is housed at the Montreal General Hospital, located at the golden square mile in the heart of downtown Montreal. Meanwhile, we are right net to Mt. Royal park with a lot of natural green space!
Lab address:
Research Institute of the McGill University Health Centre
1625 avenue des pins ouest, L11-144 and L11-132, Montreal, Quebec H3G 1A3, Canada
PI: Wei-Hsiang Huang
Phone: 514-934-1934 ext 47216 (office) ext 44895 (lab)
E-mail: wei-hsiang.huang at mcgill.ca
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