McGill | Huang Lab
Cellular and Molecular Neuroscience of
Gene Dosage-Sensitive Autism Spectrum Disorders
Mission: The Huang lab deciphers how dosage-sensitive transcriptional regulators shape brain circuit development and uses this mechanistic understanding to develop circuit-informed and gene-targeted therapies for syndromic autism spectrum disorders
Tools: We leverage novel disease models (patient-derived stem cells, neural organoids, and in vivo models), biochemistry, behavioural assays, patch-clamp electrophysiology, single-cell and multiomic approaches, tissue clearing and imaging, CRISPR and drug screens, and engineering of novel therapeutics to tackle debilitating core and comorbid symptoms associated with syndromic autism
Mission: The Huang lab deciphers how dosage-sensitive transcriptional regulators shape brain circuit development and uses this mechanistic understanding to develop circuit-informed and gene-targeted therapies for syndromic autism spectrum disorders
Tools: We leverage novel disease models (patient-derived stem cells, neural organoids, and in vivo models), biochemistry, behavioural assays, patch-clamp electrophysiology, single-cell and multiomic approaches, tissue clearing and imaging, CRISPR and drug screens, and engineering of novel therapeutics to tackle debilitating core and comorbid symptoms associated with syndromic autism
Affiliations: We are based at the Centre for Research in Neuroscience (CRN) of the Department of Neurology and Neurosurgery at McGill University. Dr. Wei-Hsiang Huang is also a member of the Azrieli Centre for Autism Research (ACAR). Dr. Huang recruits Ph.D. students from the McGill IPN.
Our lab is located at the Montreal General Hospital, within the heart of downtown Montreal, right next to Mt. Royal park with a lot of natural green space!
Lab address:
1625 avenue des pins ouest, L11-144 and L11-132, Montreal, Quebec H3G 1A3, Canada
PI: Wei-Hsiang Huang
Phone: 514-934-1934 ext 44895
E-mail: wei-hsiang.huang at mcgill.ca
Our lab is located at the Montreal General Hospital, within the heart of downtown Montreal, right next to Mt. Royal park with a lot of natural green space!
Lab address:
1625 avenue des pins ouest, L11-144 and L11-132, Montreal, Quebec H3G 1A3, Canada
PI: Wei-Hsiang Huang
Phone: 514-934-1934 ext 44895
E-mail: wei-hsiang.huang at mcgill.ca
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