Paul Hao-Cheng Chang, M.Sc.

• M.Sc. in Physiology and Pharmacology, Chang-Gung University, Taiwan​
• B.Sc. in Respiratory Care, Chang-Gung University, Taiwan
• ​2023, 2024 McGill Faculty of Medicine Internal Studentship
• 2023 McGill Faculty of Medicine MedStar Award
• ​2024 PRISMS Research Conference Travel Award
• ​2026 RI-MUHC PhD studentship
  
• Paul is interested in studying the molecular and neurobiology of ASD. In his free time, Paul enjoys cooking, wine, and outdoor activities. He also likes to watch movies, talk shows, and Esports

Publications
​Lin YC, Lee YJ, Li CX, Chang HC, Kowalczyk M, Haque M, Dragoiescu A, Loiser TT, Taylor JA, Rousseaux MWC, Huang WH
CRISPR screening identifies TRIM27 as a destabilizer of the Smith-Magenis syndrome protein RAI1
Genetics, 2026 May 16:iyag121. doi: 10.1093/genetics/iyag121​

Chang YT, Lee YJ, Haque M, Chang HC, Javed S, Lin YC, Abramovitz J, Chin G, Khamis A, Raja R, Murai KK, Huang WH
Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys
J Comp Neurol., 2024 Jan;532(1):e25589. doi: 10.1002/cne.25589.​

Javed S, Chang YT, Cho Y, Lee YJ, Chang HC, Haque M, Lin YC, Huang WH
Smith-Magenis syndrome protein Rai1 regulates body weight homeostasis through hypothalamic Bdnf-producing neurons and neurotrophin downstream signalling
Elife, 2023;12:RP90333. doi.org/10.7554/eLife.90333.3

​Chang HC, Lee YJ, Javed S, Haque M, Chang YT, Lin YC, Oram C, Huang WH 
rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice
J Biol Chem, 2023 Jan, doi: 10.1016/j.jbc.2022.102728