Huang Lab @ McGill
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  • Montreal
Debbie Ya-Ting Chang, Ph.D.
  • Postdoc research in Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, USA
  • Ph.D. in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taiwan​
  • ​2023 RI-MUHC Postdoctoral Fellowship
  • Debbie is interested in studying the mechanism of neuronal hyperexcitability in ASD models. In her free time, Debbie enjoys food, coffee and outdoor activities. She also likes to read fictions, watch comedies, and try her own recipes
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Publications
Chang HC, Lee YJ, Javed S, Haque M, Chang YT, Lin YC, Oram C, Huang WH 
rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice
J Biol Chem, 2023 Jan, doi: 10.1016/j.jbc.2022.102728
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Chang YT, Kowalczyk M, Fogerson PM, Lee JY, Haque M, Adams EL, Wang DC, DeNardo LA, Tessier-Lavigne M, Huguenard JR, Luo L, Huang WH
Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome
Proc Natl Acad Sci USA, 2022 Oct, doi.org/10.1073/pnas.2210122119

Chang, Y.T.,  Ling J, Gu JG. (2021) Effects of GABA B receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation. Mol. Pain doi: 10.1177/17448069211042963.

Kanda H, Ling J, Chang, Y.T., Erol F, Viatchenko-Karpinski V, Yamada A, Noguchi K, Gu JG. (2021) Kv4.3 channel dysfunction contributes to trigeminal neuropathic pain manifested with orofacial cold hypersensitivity in rats. J Neurosci. doi: 10.1523/JNEUROSCI.2036-20.2021.

Chang C.S., Liao, C.C., Liou A.T., Chang Y.S., Chang, Y.T., Tzeng, B.H., Chen, C.C., Shih, C. (2019) Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model. Sci.Reports.9:11108

Chang, Y.T., Chen W.H., Shih, H. C., Min, M.Y., Shyu, B.C., and Chen, C.C. (2019) Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia. Pain.160(5):1208-1223. (Editor’s Choice)

Chen W.H., Chang, Y.T., Chen, Y.C., Cheng, S.J., and Chen, C.C. (2018) Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming. Pain. 159(5):907-918

Cheng, Y.F.*, Chang, Y.T.*, Chen, W.H., Shih, H. C. Chen, Y. H., Shyu, B.C., and Chen, C.C. (2017) Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus. Nature Communications. 8:826. (*The authors contributed equally to this work)

Chang, Y.M., Ling, L., Chang, Y.T, Chang, Y. W., Li, W. H., Shih, A. C. & Chen., C. C. (2017) Three TF Co-expression Modules Regulate Pressure-Overload Cardiac Hypertrophy in Male Mice. Scientific Reports. 7: 7560

Chang, Y.W., Chang, Y.T., Wang, Q., Lin, J., Chen,Y.J. & Chen,C.C.(2013) Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy. Mol Cell Proteomics,12(11):3094-107

Hsu, S.C., Chang, Y.T. & Chen, C.C. (2013) Early Growth Response 1 is an Early Signal Inducing Cav3.2 T-type Calcium Channels during Cardiac Hypertrophy. Cardiovasc Res, 100(2):222-30

Cheng, S.J., Chen, C.C., Yang, H.W., Chang,Y.T., Bai, S.W., Chen, C.C., Yen, C.T. & Min, M.Y. (2011) Role of extracellular signal-regulated kinase in synaptic transmission and plasticity of a nociceptive input on capsular central amygdaloid neurons in normal and acid-induced muscle pain mice. J Neurosci 2011, 31(6):2258 –2270

Chen, W.G., Liu,I.Y., Chang, Y.T., Chen, Y.C., Chen,C.C., Yen, C.T., Shin, H.-S., & Chen, C.C. (2010) Cav3.2 T-type Ca2+ channel dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci 2010, 30(31):10360-10368 (evaluated by Faculty of 1000 Medicine)

Chiang, C.S. Huang, C. H., Chieng, H.L, Chang, Y.T., Chang, D., Chen, J.J., Chen, Y.C., Chen, Y.H., Shin, H.-S., Campbell, K.P., & Chen, C.C. (2009) Cav3.2 T-type Ca2+ channel is required for pressure overload-induced cardiac hypertrophy in mice. Circ Res 104(4). 522-530. (evaluated by Faculty of 1000 Biology and Faculty of 1000 Medicine)
  • About the lab
  • Group Leader
  • Research
  • Publications
  • Group members
  • Resources
  • Montreal