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Debbie Ya-Ting Chang, Ph.D.
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Publications
Chang YT, Lee YJ, Haque M, Chang HC, Javed S, Lin YC, Abramovitz J, Chin G, Khamis A, Raja R, Murai KK, Huang WH
Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys
J Comp Neurol., 2024 Jan;532(1):e25589. doi: 10.1002/cne.25589.
Javed S, Chang YT, Cho Y, Lee YJ, Chang HC, Haque M, Lin YC, Huang WH
Smith-Magenis syndrome protein Rai1 regulates body weight homeostasis through hypothalamic Bdnf-producing neurons and neurotrophin downstream signalling
Elife, 2023;12:RP90333. doi.org/10.7554/eLife.90333.3
Chang HC, Lee YJ, Javed S, Haque M, Chang YT, Lin YC, Oram C, Huang WH
rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice
J Biol Chem, 2023 Jan, doi: 10.1016/j.jbc.2022.102728
Chang YT, Kowalczyk M, Fogerson PM, Lee JY, Haque M, Adams EL, Wang DC, DeNardo LA, Tessier-Lavigne M, Huguenard JR, Luo L, Huang WH
Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome
Proc Natl Acad Sci USA, 2022 Oct, doi.org/10.1073/pnas.2210122119
Chang, Y.T., Ling J, Gu JG. (2021) Effects of GABA B receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation. Mol. Pain doi: 10.1177/17448069211042963.
Kanda H, Ling J, Chang, Y.T., Erol F, Viatchenko-Karpinski V, Yamada A, Noguchi K, Gu JG. (2021) Kv4.3 channel dysfunction contributes to trigeminal neuropathic pain manifested with orofacial cold hypersensitivity in rats. J Neurosci. doi: 10.1523/JNEUROSCI.2036-20.2021.
Chang C.S., Liao, C.C., Liou A.T., Chang Y.S., Chang, Y.T., Tzeng, B.H., Chen, C.C., Shih, C. (2019) Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model. Sci.Reports.9:11108
Chang, Y.T., Chen W.H., Shih, H. C., Min, M.Y., Shyu, B.C., and Chen, C.C. (2019) Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia. Pain.160(5):1208-1223. (Editor’s Choice)
Chen W.H., Chang, Y.T., Chen, Y.C., Cheng, S.J., and Chen, C.C. (2018) Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming. Pain. 159(5):907-918
Cheng, Y.F.*, Chang, Y.T.*, Chen, W.H., Shih, H. C. Chen, Y. H., Shyu, B.C., and Chen, C.C. (2017) Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus. Nature Communications. 8:826. (*The authors contributed equally to this work)
Chang, Y.M., Ling, L., Chang, Y.T, Chang, Y. W., Li, W. H., Shih, A. C. & Chen., C. C. (2017) Three TF Co-expression Modules Regulate Pressure-Overload Cardiac Hypertrophy in Male Mice. Scientific Reports. 7: 7560
Chang, Y.W., Chang, Y.T., Wang, Q., Lin, J., Chen,Y.J. & Chen,C.C.(2013) Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy. Mol Cell Proteomics,12(11):3094-107
Hsu, S.C., Chang, Y.T. & Chen, C.C. (2013) Early Growth Response 1 is an Early Signal Inducing Cav3.2 T-type Calcium Channels during Cardiac Hypertrophy. Cardiovasc Res, 100(2):222-30
Cheng, S.J., Chen, C.C., Yang, H.W., Chang,Y.T., Bai, S.W., Chen, C.C., Yen, C.T. & Min, M.Y. (2011) Role of extracellular signal-regulated kinase in synaptic transmission and plasticity of a nociceptive input on capsular central amygdaloid neurons in normal and acid-induced muscle pain mice. J Neurosci 2011, 31(6):2258 –2270
Chen, W.G., Liu,I.Y., Chang, Y.T., Chen, Y.C., Chen,C.C., Yen, C.T., Shin, H.-S., & Chen, C.C. (2010) Cav3.2 T-type Ca2+ channel dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci 2010, 30(31):10360-10368 (evaluated by Faculty of 1000 Medicine)
Chiang, C.S. Huang, C. H., Chieng, H.L, Chang, Y.T., Chang, D., Chen, J.J., Chen, Y.C., Chen, Y.H., Shin, H.-S., Campbell, K.P., & Chen, C.C. (2009) Cav3.2 T-type Ca2+ channel is required for pressure overload-induced cardiac hypertrophy in mice. Circ Res 104(4). 522-530. (evaluated by Faculty of 1000 Biology and Faculty of 1000 Medicine)
Chang YT, Lee YJ, Haque M, Chang HC, Javed S, Lin YC, Abramovitz J, Chin G, Khamis A, Raja R, Murai KK, Huang WH
Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys
J Comp Neurol., 2024 Jan;532(1):e25589. doi: 10.1002/cne.25589.
Javed S, Chang YT, Cho Y, Lee YJ, Chang HC, Haque M, Lin YC, Huang WH
Smith-Magenis syndrome protein Rai1 regulates body weight homeostasis through hypothalamic Bdnf-producing neurons and neurotrophin downstream signalling
Elife, 2023;12:RP90333. doi.org/10.7554/eLife.90333.3
Chang HC, Lee YJ, Javed S, Haque M, Chang YT, Lin YC, Oram C, Huang WH
rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice
J Biol Chem, 2023 Jan, doi: 10.1016/j.jbc.2022.102728
Chang YT, Kowalczyk M, Fogerson PM, Lee JY, Haque M, Adams EL, Wang DC, DeNardo LA, Tessier-Lavigne M, Huguenard JR, Luo L, Huang WH
Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome
Proc Natl Acad Sci USA, 2022 Oct, doi.org/10.1073/pnas.2210122119
Chang, Y.T., Ling J, Gu JG. (2021) Effects of GABA B receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation. Mol. Pain doi: 10.1177/17448069211042963.
Kanda H, Ling J, Chang, Y.T., Erol F, Viatchenko-Karpinski V, Yamada A, Noguchi K, Gu JG. (2021) Kv4.3 channel dysfunction contributes to trigeminal neuropathic pain manifested with orofacial cold hypersensitivity in rats. J Neurosci. doi: 10.1523/JNEUROSCI.2036-20.2021.
Chang C.S., Liao, C.C., Liou A.T., Chang Y.S., Chang, Y.T., Tzeng, B.H., Chen, C.C., Shih, C. (2019) Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model. Sci.Reports.9:11108
Chang, Y.T., Chen W.H., Shih, H. C., Min, M.Y., Shyu, B.C., and Chen, C.C. (2019) Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia. Pain.160(5):1208-1223. (Editor’s Choice)
Chen W.H., Chang, Y.T., Chen, Y.C., Cheng, S.J., and Chen, C.C. (2018) Spinal protein kinase C/extracellular signal-regulated kinase signal pathway mediates hyperalgesia priming. Pain. 159(5):907-918
Cheng, Y.F.*, Chang, Y.T.*, Chen, W.H., Shih, H. C. Chen, Y. H., Shyu, B.C., and Chen, C.C. (2017) Cardioprotection induced in a mouse model of neuropathic pain via anterior nucleus of paraventricular thalamus. Nature Communications. 8:826. (*The authors contributed equally to this work)
Chang, Y.M., Ling, L., Chang, Y.T, Chang, Y. W., Li, W. H., Shih, A. C. & Chen., C. C. (2017) Three TF Co-expression Modules Regulate Pressure-Overload Cardiac Hypertrophy in Male Mice. Scientific Reports. 7: 7560
Chang, Y.W., Chang, Y.T., Wang, Q., Lin, J., Chen,Y.J. & Chen,C.C.(2013) Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy. Mol Cell Proteomics,12(11):3094-107
Hsu, S.C., Chang, Y.T. & Chen, C.C. (2013) Early Growth Response 1 is an Early Signal Inducing Cav3.2 T-type Calcium Channels during Cardiac Hypertrophy. Cardiovasc Res, 100(2):222-30
Cheng, S.J., Chen, C.C., Yang, H.W., Chang,Y.T., Bai, S.W., Chen, C.C., Yen, C.T. & Min, M.Y. (2011) Role of extracellular signal-regulated kinase in synaptic transmission and plasticity of a nociceptive input on capsular central amygdaloid neurons in normal and acid-induced muscle pain mice. J Neurosci 2011, 31(6):2258 –2270
Chen, W.G., Liu,I.Y., Chang, Y.T., Chen, Y.C., Chen,C.C., Yen, C.T., Shin, H.-S., & Chen, C.C. (2010) Cav3.2 T-type Ca2+ channel dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J Neurosci 2010, 30(31):10360-10368 (evaluated by Faculty of 1000 Medicine)
Chiang, C.S. Huang, C. H., Chieng, H.L, Chang, Y.T., Chang, D., Chen, J.J., Chen, Y.C., Chen, Y.H., Shin, H.-S., Campbell, K.P., & Chen, C.C. (2009) Cav3.2 T-type Ca2+ channel is required for pressure overload-induced cardiac hypertrophy in mice. Circ Res 104(4). 522-530. (evaluated by Faculty of 1000 Biology and Faculty of 1000 Medicine)