The Huang lab is interested in studying the molecular, cellular, circuit, and behavioral functions of genes involved in autism spectrum disorders (ASDs) and epilepsy. We will apply new molecular and neuroscience techniques to achieve this goal. Currently, we are interested in the following areas:
How do ASD-risk genes impair neural activity and circuit function?
To answer this question, we will use modern neuroscience technologies including electrophysiology, calcium imaging, viral-mediated circuit tracing, whole brain clearing and imaging, optogenetic, and neurobehavioral assays to study how ASD-risk genes alter neural functions on multiple levels
How do somatic mosaic mutations cause
autism and epilepsy?
To address this question, we will use an elegant genetic
approach, mosaic analysis of double markers (MADM) to
perform single-cell analysis and dissect the cell-
autonomous v.s. non-cell-autonomous functions of ASD-
risk genes in neural development