Alessia Pietrantonio, M.Sc.
- M.Sc., Integrated Program in Neuroscience, McGill University, Canada
- B.Sc. in Pharmacology (first-in-class honours), McGill University, Canada
- 2024-2026 FRQS MSc Fellowship
- Alessia is interested in dissecting the molecular and neural mechanisms underlying neurodevelopmental and psychiatric disorders using iPSC-derived neural models.
- enjoys .
Publications
Pietrantonio A, Rochefort D, Castonguay CE, Tiefensee-Ribeiro C, Liu Y, Abuzgaya M, Alda M, Rouleau G, Khayachi A, Milnerwood A. Decoding the bipolar disorder neuronal secretome: identifying a biomarker for lithium responsiveness and assessing network activity. (In preparation).
Farhangdoost N, Pietrantonio A, Liu Y, Liao C, Rochefort D, Pacis A, Alda M, Dion PA, Chaumette B, Khayachi A, & Rouleau GA. Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes. Scientific Reports, 2025, 15(1). https://doi.org/10.1038/s41598-025-21716-w
Kamesh A, Kadgien CA, Kuhlmann N, Coady S, Pietrantonio A, Cousineau Y, Khayachi A, Jurado Santos A, Hurley EP, Barron JC, Parsons MP, Milnerwood, AJ. Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition. Npj Parkinson's Disease, 2025, 11(1). https://doi.org/10.1038/s41531-025- 00948-7
Farhangdoost N, Liao C, Liu Y, Rochefort D, Aboasali F, Pietrantonio A, Alda M, Dion PA, Chaumette B, Khayachi A, Rouleau GA. Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophrenia. Molecular Psychiatry, 2025, 30(10), 4543–4557. https://doi.org/10.1038/s41380-025-03040-x
Khayachi A, Abuzgaya M, Liu Y, Jiao C, Dejgaard K, Schorova L, Kamesh A, He Q, Cousineau Y, Pietrantonio A, Farhangdoost N, Castonguay CE, Chaumette B, Alda M, Rouleau GA, Milnerwood AJ. Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorder. EBioMedicine, 2024 104, 105161. https://doi.org/10.1016/j.ebiom.2024.105161
Pietrantonio A, Rochefort D, Castonguay CE, Tiefensee-Ribeiro C, Liu Y, Abuzgaya M, Alda M, Rouleau G, Khayachi A, Milnerwood A. Decoding the bipolar disorder neuronal secretome: identifying a biomarker for lithium responsiveness and assessing network activity. (In preparation).
Farhangdoost N, Pietrantonio A, Liu Y, Liao C, Rochefort D, Pacis A, Alda M, Dion PA, Chaumette B, Khayachi A, & Rouleau GA. Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changes. Scientific Reports, 2025, 15(1). https://doi.org/10.1038/s41598-025-21716-w
Kamesh A, Kadgien CA, Kuhlmann N, Coady S, Pietrantonio A, Cousineau Y, Khayachi A, Jurado Santos A, Hurley EP, Barron JC, Parsons MP, Milnerwood, AJ. Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition. Npj Parkinson's Disease, 2025, 11(1). https://doi.org/10.1038/s41531-025- 00948-7
Farhangdoost N, Liao C, Liu Y, Rochefort D, Aboasali F, Pietrantonio A, Alda M, Dion PA, Chaumette B, Khayachi A, Rouleau GA. Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophrenia. Molecular Psychiatry, 2025, 30(10), 4543–4557. https://doi.org/10.1038/s41380-025-03040-x
Khayachi A, Abuzgaya M, Liu Y, Jiao C, Dejgaard K, Schorova L, Kamesh A, He Q, Cousineau Y, Pietrantonio A, Farhangdoost N, Castonguay CE, Chaumette B, Alda M, Rouleau GA, Milnerwood AJ. Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorder. EBioMedicine, 2024 104, 105161. https://doi.org/10.1016/j.ebiom.2024.105161